Mebeverine (ميبيفيرين)

Introduction:

Mebeverine is a medication used to relax tight muscles within the digestive system. It is used to treat various gastrointestinal symptoms including abdominal cramps, spasms and pain. This drug is a musculotropic antispasmodic and belongs to the drug class mebeverinium.

Indications:

Mebeverine is indicated for the relief of symptoms associated with functional gastrointestinal disorders such as irritable bowel syndrome (IBS), spasm due to lower urinary tract infection, diverticulitis, as well as non-ulcer dyspepsia.

Mechanism of Action:

Mebeverine is a musculotropic antispasmodic and belongs to the drug class mebeverinium. It works by relaxing the muscles in the walls of the intestines. It has antispasmodic effects that reduce the symptoms of functional gastrointestinal disorders such as abdominal pain, constipation, diarrhea, and bloating.

How long does it take to work?

Mebeverine can work within a few hours and should provide relief within 24 hours of taking the first dose. This means that you may not feel better from the first dose but should start to feel relief in the following days.

Absorption:

Mebeverine is absorbed in the small intestine and is rapidly distributed to the liver, where it is metabolized into active and inactive metabolites.

Route of Elimination:

Mebeverine is rapidly converted to its metabolites in the liver and then excreted in the urine and bile.

Dosage:

Mebeverine is available as tablets, capsules, and liquid solution. The usual dose is 20-40mg three times a day with meals. In some cases, your doctor may recommend increasing the dose to 8mg three times a day. The dosage must be adjusted according to the patient's condition and symptoms.

Administration:

Mebeverine should be taken with food or a full glass of water. It should not be chewed or divided. It should be swallowed whole.

Side effects:

The most common side effects of Mebeverine are headache, loss of appetite, constipation, nausea, and dry mouth. Some less common side effects include anxiety, confusion, dizziness, drowsiness, insomnia, and fatigue. If any of these side effects persist or worsen, contact your doctor immediately.

Toxicity:

Mebeverine has no known toxicity and is considered to be safe for long-term use. If an excessive amount of the drug is taken, contact a healthcare professional for further instructions.

Precautions:

Mebeverine should not be taken if you are pregnant or breastfeeding. It can also cause drowsiness and dizziness and should be avoided if you plan to drive or operate machinery. Also, if you have any liver or kidney conditions, consult your doctor before taking the medication. In addition, people with history of fits and seizures should also consult their doctor.

Interactions:

Mebeverine may interact with other drugs including antidepressants, anticonvulsants, calcium channel blockers, narcotics, hormones, etc. Therefore, it is important to inform your doctor or pharmacist of all the medications you are taking. This includes both prescription and non-prescription drugs.

Disease Interactions:

Mebeverine can interact with other medical conditions such as kidney disease, liver disease, or if you have had a recent heart attack. Therefore, it is important to tell your doctor or pharmacist if you have any other medical conditions.

Drug Interactions:

Mebeverine may interact with other drugs including calcium channel blockers, narcotics, antidepressants, anticonvulsants, hormones, etc. Therefore, it is important to inform your doctor or pharmacist of all the medications you are taking.

Food Interactions:

Mebeverine can interact with certain foods such as foods high in sugar and fat. It is important to consume meals that are rich in fibre, low in fat, and low in sugar.

Pregnancy Use:

Mebeverine should not be taken during pregnancy as it can cause harm to the fetus. Consult your doctor if you are pregnant or plan to become pregnant while taking this medication.

Lactation Use:

Mebeverine should not be taken while breastfeeding. It may cause harm to the baby if it passes through breast milk. Consult your doctor if you plan to take this medication while breastfeeding.

Acute Overdose:

If an overdose of Mebeverine is suspected, seek medical attention immediately. Symptoms of an overdose may include fever, rapid heartbeat, confusion, seizures, and irregular breathing.

Contraindications:

Mebeverine is contraindicated in patients with a known hypersensitivity to mebeverine or any of its ingredients. It is also contraindicated in patients with narrow-angle glaucoma, stenosing peptic ulcer, myasthenia gravis, tachycardia, cardiovascular disease, and in patients younger than 6 years of age.

Use Direction:

Mebeverine should be taken as recommended by your doctor. It is usually taken three times a day after meals with a full glass of water. It should not be chewed or divided.

Storage Conditions:

Mebeverine should be stored at room temperature, away from direct sunlight and heat. It should also be kept out of reach of children and pets.

Volume of Distribution:

Mebeverine has a volume of distribution of 0.15-2.01 L/kg.

Half Life:

The half-life of Mebeverine is 2-4 hours.

Clearance:

The clearance rate of Mebeverine is 0.32-1.07 mL/min/kg.

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