Terbinafine Hydrochloride

Arabic Generic Name

تيربينافين هيدروكلورايد

Introduction

Terbinafine hydrochloride is an antifungal drug that is used to treat a variety of fungal infections such as ringworm, athlete’s foot, and jock itch. It is available in tablets, gel, and cream form. It is also available as an ointment.

Indication

Terbinafine hydrochloride can be used to treat fungal infections of the skin, nails, and feet. It is also used to treat certain types of toenail fungus.

Mechanism of Action

Terbinafine hydrochloride works by inhibiting the growth of fungus cells. It does this by blocking the enzyme cyclooxygenase, which is required for the growth of fungal cells. This leads to the death of the fungus cells and prevents them from spreading.

How Long Does it Take to Work?

It typically takes between 2-4 weeks for terbinafine hydrochloride to work. The effectiveness of the drug depends on the severity and type of infection being treated.

Absorption

Terbinafine hydrochloride is well absorbed from the gastrointestinal tract and is metabolized in the liver. It then enters the bloodstream and can be found in high concentrations in the skin.

Route of Elimination

Terbinafine hydrochloride is eliminated mostly in the urine and a small amount in the feces.

Dosage

For topical applications, the recommended dose is 50 mg of terbinafine hydrochloride cream applied to the affected area once or twice per day. For oral applications, the recommended dose is 250 mg taken once a day.

Administration

Terbinafine hydrochloride can be taken orally or applied topically. It is important to follow the directions on the product label closely in order to ensure proper use.

Side Effects

Common side effects of terbinafine hydrochloride include itching, burning, redness, and rash. Side effects such as nausea, vomiting, and diarrhea may occur when taking it orally.

Toxicity

Terbinafine hydrochloride is usually well tolerated. However, it is possible to have an allergic reaction to its ingredient. Symptoms of an allergic reaction may include difficulty breathing, swelling of the lips, tongue, or face, and hives. Contact a doctor immediately if any of these symptoms occur.

Precautions

Patients taking terbinafine hydrochloride should avoid exposure to direct sunlight. They should also avoid drinking alcohol while taking the medication. If pregnant or breastfeeding, it is important to talk to a doctor before using this medication.

Interaction

Terbinafine hydrochloride may interact with several other medications. Therefore, it is important to tell a doctor about all medications being taken before taking this medication.

Disease Interaction

Patients with kidney or liver disease should talk to their doctor before taking terbinafine hydrochloride. This drug may affect the levels of electrolytes such as potassium in the body, which could be dangerous for these patients.

Drug Interaction

Terbinafine hydrochloride may interact with anticoagulants, diuretics, and certain other medications. Therefore, it is important to inform a doctor of all medications being taken before taking this medication.

Food Interactions

Terbinafine hydrochloride should not be taken with grapefruit or grapefruit juice.

Pregnancy Use

This medication is not recommended for use during pregnancy. It could have harmful effects on the fetus.

Lactation Use

It is not known if terbinafine hydrochloride passes into breast milk. Therefore, it is recommended to talk to a doctor before taking this medication while breastfeeding.

Acute Overdose

If an overdose of terbinafine hydrochloride occurs, it is important to contact a poison control center or seek medical help immediately. Overdoses can cause symptoms such as nausea, vomiting, and stomach pain.

Contraindication

Terbinafine hydrochloride should not be used in patients who are allergic to terbinafine hydrochloride or any of its ingredients.

Use Direction

Terbinafine hydrochloride should be used as directed by the doctor. Follow doctor’s instructions carefully in order to ensure proper use of the medication.

Storage Conditions

Terbinafine hydrochloride should be stored at room temperature away from heat and moisture. Keep it out of reach of children and pets.

Volume of Distribution

The average volume of distribution of terbinafine hydrochloride is 16.3 L/kg.

Half-Life

The half-life of terbinafine hydrochloride is 36.5 hours.

Clearance

The average clearance of terbinafine hydrochloride is 0.39 L/hr/kg.

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