Famotidine (فموتيدين)

Introduction

Famotidine (Ubral) is a drug in the H2 blockers elass which is used to treat and prevent ulcers in the stomach and intestines. It is available in tablets, capsules and a liquid suspension, and is generally taken once or twice daily. It is also used for the treatment of heartburn and indigestion.

Indication

Famotidine is used to treat gastroesophageal reflux disease (GERD), stomach ulcers, and gastric hyperacidity. It helps reduce symptoms such as heartburn, difficulty swallowing, and persistent coughing. It is also used to alleviate symptoms associated with stomach and intestinal ulcers.

Mechanism of action

Famotidine works by blocking the production of acid in the stomach. It does this by blocking the action of histamine on the stomach cells, inhibiting the production of acid. It also provides relief from acid-related pain and discomfort by increasing the pH levels of the stomach.

How long does it take to work?

Famotidine usually takes effect within 30 minutes. It continues to work for up to 12 hours, providing relief from acid-related pain and discomfort.

Absorption

Famotidine is rapidly and almost completely absorbed from the gastrointestinal tract after oral administration. The peak plasma concentrations are achieved within 1-3 hours.

Route of Elimination

Famotidine is eliminated via the kidneys. It is excreted as metabolites or as unchanged active ingredients. It has a half-life of 2-3 hours.

Dosage

The recommended dose of Famotidine for adults is 20mg twice daily. The dosage for children may vary depending on the age and weight of the patient. It is best to consult a doctor before administering this drug to a child.

Administration

Famotidine should be taken orally with or without food. It can be taken with or without water, but it must be taken as directed. To ensure that it works correctly, it should be taken at the same time each day.

Side Effects

The most common side effects associated with Famotidine may include: headache, nausea, vomiting, abdominal pain, constipation, diarrhea, dizziness, and fatigue. Serious side effects may include: rapid or irregular heartbeat, chest pain, confusion, and severe or persistent abdominal pain.

Toxicity

Famotidine is safe and its side effects are generally mild and transient. There is no evidence of serious toxicity when administered within the recommended dose.

Precaution

Famotidine should be used with caution in patients with a history of renal impairment, heart problems, or liver disease. It should also be used with caution in the elderly. Special precautions may also be required if taking other medicines, so it is best to consult a doctor before taking this drug.

Interaction

Famotidine may interact with certain medicines, such as anticoagulants, proton pump inhibitors, and antibiotics. It can also interact with herbal supplements, such as St. John’s Wort and valerian root. It is best to consult a doctor before starting any new medicines or supplements.

Disease Interaction

Famotidine should be used with caution in patients with certain metabolic diseases, such as porphyria, diabetes, or thyroid disorders. Patients with asthma or allergies should also use caution when taking this medication.

Drug Interaction

Famotidine may interact with certain drugs such as antifungals, cyclosporine, chloramphenicol, and warfarin. Consult your doctor if taking any of these drugs. It may also interact with certain vitamins, minerals, as well as herbal supplements.

Food Interaction

Famotidine may interact with certain foods, such as alcoholic beverages, caffeine, and citrus. It is best to avoid or limit the consumption of these foods while taking Famotidine.

Pregnancy Use

Famotidine is not generally recommended for use during pregnancy. If you are pregnant, consult your doctor before taking this drug.

Lactation Use

Famotidine is not recommended for use during lactation. If you are taking this medication, consult your doctor before breastfeeding.

Acute Overdose

In case of an acute overdose of Famotidine, seek medical attention immediately. Overdose symptoms may include fast or irregular heartbeat, difficulty breathing, and seizures.

Contraindication

Famotidine is contraindicated in patients with known hypersensitivity to the drug. It should also be used with caution in patients with a history of renal impairment, heart problems, or liver disease.

Use Direction

Famotidine should be taken orally with or without food, as directed by your doctor. The recommended dose for adults is 20mg twice daily. The dose for children may vary depending on the age and weight of the patient.

Storage Condition

Famotidine should be stored at room temperature, away from heat and direct light. It should be kept away from children and pets.

Volume of Distribution

The volume of distribution of Famotidine is 3.5L/kg.

Half-Life

The half-life of Famotidine is 2-3 hours.

Clearance

The clearance of Famotidine is 1.3mL/min/kg.

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