Ramipril

Introduction

Ramipril is an angiotensin converting enzyme (ACE) inhibitor used to treat high blood pressure (hypertension) and congestive heart failure. It is also used to reduce the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary artery disease, or other risk factors.

Indication

Ramipril is used for the treatment of hypertension, heart failure, and to reduce the risk of myocardial infarction and stroke in people with diabetes or other risk factors for coronary artery disease as well as preventing renal and retinal complications of diabetes. It may also be used for other conditions as determined by your doctor.

Mechanism of Action

Ramipril works by blocking the production of the hormone angiotensin II. This causes blood vessels to relax, reducing pressure in the blood vessels and improving blood flow. It also helps reduce the production of excess fluid in the body, which can help reduce symptoms of congestive heart failure.

How Long Does It Take To Work?

Ramipril generally takes at least a few weeks to reach its full effect. However, some people may experience an improvement in symptoms within 1-2 weeks.

Absorption

Ramipril is rapidly and completely absorbed after oral administration. Peak concentrations of Ramipril in the bloodstream occur within 4-5 hours.

Route of Elimination

Ramipril is eliminated primarily via the kidneys, with less than 5% being eliminated in the feces.

Dosage

The dose of Ramipril varies based on the condition being treated and the individual’s response to treatment. Commonly, once daily dosing is recommended, however, it can also be taken twice daily. The usual starting dose is 2.5 to 5mg once daily, which may be increased by your healthcare provider if necessary.

Administration

Ramipril should be taken with food and a full glass of water to reduce the risk of stomach upset. It should be taken at the same time every day for maximum effectiveness.

Side Effects

Common side effects of Ramipril include: dizziness, headache, fatigue, dry cough, nausea, diarrhea, and hypotension. Some of the more serious side effects include anemia, rash, decreased white blood cell count, liver damage, or kidney damage.

Toxicity

An overdose of Ramipril can be fatal, although it is not well documented. Symptoms of overdose include dizziness, confusion, drowsiness, breathing difficulties, and an increased heart rate. Seek emergency medical attention if an overdose is suspected.

Precautions

Before taking Ramipril, tell your doctor or pharmacist if you have any allergies, particularly to ACE inhibitors, and any other medications or substances. Be sure to tell your healthcare provider if you have any other medical conditions or are pregnant or breast-feeding.

Interactions

Ramipril may interact with certain medications and herbal supplements. Before taking Ramipril, it is important to tell your doctor or pharmacist about all of the medications and herbal supplements you are taking.

Disease Interaction

Ramipril may interfere with certain diseases, such as diabetes, congestive heart failure, liver or kidney disease, and may worsen symptoms in people with genetically-linked disorders such as Marfan and Ehlers-Danlos syndromes.

Drug Interaction

Ramipril may interact with certain drugs, including diuretics and anti-inflammatory drugs. Notify your doctor before taking Ramipril if you are taking any of these medications.

Food Interactions

Foods containing potassium or sodium may affect the absorption of Ramipril, so it is important to talk to your doctor or pharmacist about any dietary modifications you may need to make while taking Ramipril.

Pregnancy Use

Ramipril is a pregnancy category C drug, which means that its effects on an unborn baby are not yet known. It is not recommended to take this drug if you are pregnant or planning to become pregnant.

Lactation Use

It is not known whether Ramipril passes into breast milk. It is not recommended to take this drug if you are breastfeeding.

Acute Overdose

Signs and symptoms of an acute overdose of Ramipril may include dizziness, confusion, drowsiness, breathing difficulties, and an increased heart rate. Seek immediate medical attention if an overdose is suspected.

Contraindication

Ramipril is contraindicated in people who are allergic to ACE inhibitors, or anyone with severe kidney, liver, or heart disease. It is not recommended for use in people with hereditary angioedema.

Use Direction

Ramipril should be taken exactly as prescribed by your doctor. Do not take larger or smaller doses than prescribed and do not take it more or less often than instructed. It should be taken with food and a full glass of water to reduce the risk of stomach upset.

Storage Condition

Ramipril should be stored at room temperature, away from moisture and light.

Volume of Distribution

The volume of distribution of Ramipril is approximately 0.6L/kg.

Half Life

The elimination half-life of Ramipril is approximately 2.6 hours.

Clearance

The clearance of Ramipril is approximately 25 – 35 mL/min.

Generic Name in Arabic

راميبريل (Ramipril)

Here you find in details version of راميبريل وينثروب